HOPO 14-1
HOPO 14-1 es un molecula testate como medicamento contra le contamination per radioelementos (en) in le caso de accidente nuclear o attacco per bomba radiologic (en).[1][2] Iste substantia active es le ligante (en) hydroxypyridinone 3,4,3-LI(1,2-HOPO), un chelante (fr) potente.[1][3] Es administrate per via oral.[4]
HOPO 14-1 es designate per le chimista Rebecca Abergel del Lawrence Berkeley National Laboratory pro se ligar con metales ponderose (en) presente in le corpore e formar un complexo naturalmente excretate per organismo.[5] Es active contra numerose elementos cuje uranium, neptunium, plutonium, americium e curium.[4]
Es commercialisate per HOPO Therapeutics, un compania specialisate in le curamento de intoxicationes con metales ponderose. Poterea esser alsi effective contra intoxicationes con plumbo, o le gadolinium del agentes de contrasto utilisate in imageria per resonantia magnetic (fr).[6][7][8]
Referentias
modificar- ↑ 1,0 1,1 First-in-human trial of oral drug to remove radioactive contamination begins (anglese) (2023-05-15).
- ↑ "Dirty-bomb antidote: Drug trial begins in US" (in en-GB), BBC News (2023-05-16).
- ↑ "Chelation Behaviors of 3,4,3-LI(1,2-HOPO) with Lanthanides and Actinides Implicated by Molecular Dynamics Simulations" (March 2023). Inorganic Chemistry 62 (10): 4304–4313. doi:. PMID 36847745.
- ↑ 4,0 4,1 Un médicament oral destiné à éliminer une contamination radioactive testé chez l'humain, Science & Avenir
- ↑ "Biomimetic actinide chelators: an update on the preclinical development of the orally active hydroxypyridonate decorporation agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)" (September 2010). Health Physics 99 (3): 401–407. doi:. PMID 20699704.
- ↑ "Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents" (March 2018). Scientific Reports 8 (1): 4419. doi:. PMID 29535330. Bibcode: 2018NatSR...8.4419R.
- ↑ This Anti-Nuclear-Contimation Pill Could Also Help MRI Patients (anglese) (2019-09-12).
- ↑ Rebecca Abergel - Bakar Fellows Program (anglese) (2021-10-21).