Netrina 1

NTN1
Available structures
PDB	Ortholog search: O95631 PDBe O95631 RCSB
List of PDB id codes
	4URT
Identifiers
Aliases	NTN1, NTN1L, netrin 1, MRMV4
External IDs	OMIM: 601614 MGI: 105088 HomoloGene: 21008 GeneCards: NTN1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	9,244,000 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	68,291,649 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right auricle; ; Descending thoracic aorta; ; ascending aorta; ; popliteal artery; ; Tibial arteries; ; olfactory zone of nasal mucosa; ; apex of heart; ; parotid gland; ; mucosa of esophagus;
	Top expressed in
	Cerebral white matter; ; tunica media of zone of aorta; ; ankle joint; ; ankle; ; dermis; ; ascending aorta; ; vas deferens; ; aortic valve; ; atrium; ; myocardium of ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; cytoplasm; basement membrane;
Biological process	mammary gland duct morphogenesis; positive regulation of cell motility; axon guidance; substrate-dependent cell migration, cell extension; Cdc42 protein signal transduction; positive regulation of axon extension; inner ear morphogenesis; negative regulation of axon extension; apoptotic process; mammary gland development; positive regulation of cell population proliferation; regulation of cell migration; Ras protein signal transduction; anterior/posterior axon guidance; neuron migration; axonogenesis; nuclear migration; cell-cell adhesion; negative regulation of netrin-activated signaling pathway; regulation of synapse assembly; chemorepulsion of axon; motor neuron axon guidance; animal organ morphogenesis; tissue development; dendrite development;
	Sources:Amigo / QuickGO
Orthologs
	9423
	18208
	ENSG00000065320
	ENSMUSG00000020902
	H7BZF4; O95631
	O09118
	NM_004822
	NM_008744
	NP_004813
	NP_032770
	Wikidata
View/Edit Human	View/Edit Mouse

Il non ha versiones revidite de iste pagina, dunque su qualitate forsan non ha essite verificate.

Netrina-1 es un proteina incodate in humanes per le gene NTN1 sul chromosoma 17.^[5]^[6]

Netrina es parte de un familia de laminina-relative proteinas secretate. Se pensa que netrina-1 es implicate in axon guidantia (principalemente de axones commissural in le tubo neural) e cellular migration durante embryogenese. Mutationes e perta de expression del gene suggere un implication in cancerogenese.^[6]

Pathologia

Un mutation del gene NTN1 serea responsabile del disordine congenital de movimentos speculee (en).^[7]

Le rata urinari de netrina serea un marcator precoce del insufficientia renal acute.^[8]

Durante un hepatite acute, netrina serea superexprimite et sustenerea le inflammation^[9].

Scopo therapeutic

Le anticorpore NP137 de Netris Pharma bloca netrina-1 e inhibi in consequentia le epithelial ad mesenchymal transition implicate in tumor initiation, progression, metastases e resistentia al tractamentos.^[10]^[11]^[12]

Referentias

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000065320 - Ensembl, May 2017
↑ ^2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000020902 - Ensembl, May 2017
↑ Human PubMed Reference:.
↑ Mouse PubMed Reference:.
↑ "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas" (January 1999). Cell Growth Differ. 10 (1): 35–42. PMID 9950216.
↑ ^6,0 ^6,1 Entrez Gene: NTN1 netrin 1.
↑ Méneret A, Franz EA, Trouillard O et al. Mutations in the netrin-1 gene cause congenital mirror movements, J Clin Invest, 2017;127:3923-3936
↑ Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P, Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery, Clin J Am Soc Nephrol, 2010;5:395–401
↑ La nétrine-1, un nouvel acteur dans l’inflammation hépatique ⋅ Inserm, La science pour la santé. Inserm (2022-05-16).
↑ Mélanie Bellina & Agnès Bernet (2022-04-29). "La nétrine-1, une nouvelle cible antitumorale". Med Sci. doi:10.1051/medsci/2022038.
↑ Lengrand, J., Pastushenko, I., Vanuytven, S. et al. (2023-08-02). "Pharmacological targeting of netrin-1 inhibits EMT in cancer". Nature. doi:10.1038/s41586-023-06372-2.
↑ Cassier, P.A., Navaridas, R., Bellina, M. et al. (2023-08-02). "Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer". Nature. doi:10.1038/s41586-023-06367-z.

[refGRCh38Ensembl-1] 1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000065320 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000020902 - Ensembl, May 2017

[3] Human PubMed Reference:.

[4] Mouse PubMed Reference:.

[pmid9950216-5] "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas" (January 1999). Cell Growth Differ. 10 (1): 35–42. PMID 9950216.

[entrez-6] 6,0 ^6,1 Entrez Gene: NTN1 netrin 1.

[Méneret_2017-7] Méneret A, Franz EA, Trouillard O et al. Mutations in the netrin-1 gene cause congenital mirror movements, J Clin Invest, 2017;127:3923-3936

[Ramesh_2010-8] Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P, Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery, Clin J Am Soc Nephrol, 2010;5:395–401

[9] La nétrine-1, un nouvel acteur dans l’inflammation hépatique ⋅ Inserm, La science pour la santé. Inserm (2022-05-16).

[10] Mélanie Bellina & Agnès Bernet (2022-04-29). "La nétrine-1, une nouvelle cible antitumorale". Med Sci. doi:10.1051/medsci/2022038.

[11] Lengrand, J., Pastushenko, I., Vanuytven, S. et al. (2023-08-02). "Pharmacological targeting of netrin-1 inhibits EMT in cancer". Nature. doi:10.1038/s41586-023-06372-2.

[12] Cassier, P.A., Navaridas, R., Bellina, M. et al. (2023-08-02). "Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer". Nature. doi:10.1038/s41586-023-06367-z.

[5]

[6]

[1]

[2]

[3]

[4]

[7]

[8]

[9]

[10]

[11]

[12]