Sucralosa
Sucralosa[1] (E955) es un edulcorante artificial intense, discoperite in 1976. Su potere sucrante es circa 600 vices superior a isto del saccharosa. Es pauc caloric pro que le major parte ingerate non es decomponate per le corpore.
| Sucralosa |
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| formula chimic: C₁₂H₁₉Cl₃O₈ |
| Commons: Sucralose |
Es producite per chloration del saccharosa, reimplaciante selectivemente le gruppos hydroxy in le positiones C1, C4 e C6 pro formar un disaccharido 1,6-dichloro-1,6-didesoxyfructosa–4-chloro-4-desoxygalactosa.
Innocuitate
modificarSucralosa non es carcinogenic.[2][3] Su dose quotidian admissibile es fixate per le FDA a 15 mg/kg de massa corporal.
Un studio toxicologic in vitro monstra que le sucralosa-6-acetate, un producto de digestion del sucralosa, es genotoxic e le consumption de un soda edulcorate per die suffice a exceder le dose admissibile pro un producto genotoxic. Sucralose-6-acetate augmenta significativemente le expression de genes associate con inflammation, stress oxydative o cancere (con superior expression del gene metallothioneina 1 G (MT1G)).[4]
Un consumption importante de sucralose poterea haber un effecto immunomodulatori.[5]
Referentias
modificar- ↑ Derivation: Entitates: 1. (it) Sucralosio || 2. (es) Sucralosa || (pt) Sucralose || 3. (fr) Sucralose || 4. (en) Sucralose || Controlo: (de) Sucralose || (ru) Сукралоза || - (Extra): (la)
- ↑ "Critical review of the current literature on the safety of sucralose" (August 2017). Food and Chemical Toxicology 106 (Pt A): 324–355. doi:. PMID 28558975.
- ↑ "Sucralose Non-Carcinogenicity: A Review of the Scientific and Regulatory Rationale" (16 November 2016). Nutrition and Cancer 68 (8): 1247–1261. doi:. PMID 27652616.
- ↑ Susan S. Schiffman, Elizabeth H. Scholl, Terrence S. Furey & H. Troy Nagle (2023-05-29). "Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays". Journal of Toxicology and Environmental Health. doi:. PMID 37246822.
- ↑ Zani F, Blagih J, Gruber T, Buck MD, Jones N, Hennequart M, Newell CL, Pilley SE, Soro-Barrio P, Kelly G, Legrave NM, Cheung EC, Gilmore IS, Gould AP, Garcia-Caceres C, Vousden KH (March 2023). "The dietary sweetener sucralose is a negative modulator of T cell-mediated responses". Nature 615 (7953): 705–711. doi:. PMID 36922598.